职称/职务：副教授
E-mail: tianyizhang@126.com 通讯地址: 科技处809室
研究方向:
主要从事新药设计与合成、长白山道地药材活性成分的结构修饰与生物活性评价。
代表性成果:
（1）主持项目：
阳离子两亲性抗菌肽模拟物的设计、合成及其与生物膜作用机制研究（吉林省科技厅面上项目；2026.01-2028.12）；
新型ALK5抑制剂人参二醇的结构优化及其抗肿瘤候选药物临床前研究（吉林省科技厅医药健康重点研发项目；2023.01-2025.12）；
高效低毒膜靶向厚朴酚类衍生物的设计、合成及其抗菌活性评价（吉林省科技厅学科布局项目；2021.06-2024.06）；
三嗪类DHFR抑制剂：结构优化及抗菌活性评价（吉林省教育厅一般项目；2019.01-2020.12）。
（2）代表作著作：
C Ye, Y Zhao, CL Fan, et al. A novel fluorescent probe for sensitive detection copper in food samples and in vivo. Bioorganic Chemistry, 2026, 170:109464. 通讯作者；
C Ye, N Xiao, CL Fan, et al. A NIR fluorescent probe for dual-phase viscosity monitoring in beverage thickeners and in vivo. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 348:127124. 通讯作者；
XQ Bai, C Ye, Z Liu, et al. Synthesis and biological evaluation of isoaurone derivatives as anti-inflammatory agents. Chem Biodivers, 2025, 22:e202402073. 通讯作者；
XQ Bai, JH Wang, FT Jiao, et al. Synthesis and biological evaluation of novel aminoguanidine derivatives as potential antibacterial agents. Scientific Reports, 2024, 14(1):26896. 通讯作者；
L Zhu, C Ye, S Chen, et al. Rhodanine derivatives containing 5-aryloxypyrazole moiety as anti-inflammatory and anticancer agents. Chem Biodivers, 2024, 21(2):e202301844；
TY Zhang, XQ Bai, ZJ Zhou, et al. Dihydrotriazine derivatives display high anticancer activity and inducing apoptosis, ROS, andautophagy. Bioorganic Chemistry, 2022, 124:105813. 第一作者；
TY Zhang, CS Li, MY Cui, et al. Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents. Mol Divers, 2021, 25(2): 861−876. 第一作者；
Z C, TY Zhang, YH Sun, et al. Organocatalytic enantioselective aza-Friedel-Crafts alkylation of β-naphthols and isatin-derived ketimines via a Takemoto-type catalyst†. New J Chem, 2021, 45:10481. 共同第一作者；
XQ Bai, CS Li, MY Cui, et al. Synthesis and molecular docking studies of novel pyrimidine derivatives as potential antibacterial agents. Mol Divers, 2020, 24(4):1165−1176. 通讯作者；
TY Zhang, CJ Zheng, J Wu, et al. Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. Bioorg Med Chem Lett, 2019, 29(9):1079−1084. 第一作者。
（3）科技获奖
获得奖项：以DHFR为作用靶点的新型抗菌化合物的合成与活性研究；吉林省自然科学三等奖；2024年，排名第一
