AbstractBased on the high expression of folic acid (FA) receptors in triple-negative breast cancer cells, we encapsulated licochalcone A (LCA) in FA-modified polyethylene glycol-poly(lactic-co-glycolic) acid nanoparticles (NPs) for enhanced targeting and antitumor activity. In vitro experiments on 4T1 cells showed that NPs with FA modification exhibited excellent performance, including inhibition of ...
AbstractBackground: The encystation of Acanthamoeba castellanii has important ecological and medical significance. Blocking encystation is the key to preventing transmission and curing infections caused by A. castellanii. The formation of autophagosomes is one of the most important changes that occur during the encystation of Acanthamoeba. Our previous studies have shown that the heat shock protein ...
AbstractBacteria-induced infections have always been associated with various medical devices. The construction of an intelligent antimicrobial surface is an important challenge. In this study, we report the construction of a zwitterionic surface with good biocompatibility under physiological conditions and which shows an anti-adhesion effect on the original bacteria. Once the bacteria multiply, the ...
AbstractDihydroartemisinin (DHA), a plant-derived natural product, has recently been proven to be an effective therapeutic agent for cancer treatment. Nevertheless, the poor water solubility and low bioavailability of DHA seriously impede its clinical applications. Herein, a simple and green strategy based on the self-assembly of DHA was developed to synthesize carrier-free nanoparticles (NPs). The ...
序号课题编号项目/课题名称负责人立项机构起止时间到账经费132501368基于生物膜干涉技术探讨DEK相分离在HER2阳性胃癌获得性耐药中的作用机制孙洁国家自然科学基金2026.01-2028.1260万232371548基于纳米活细胞成像技术的HSPs调控棘阿米巴成囊机制研究冯宪敏国家自然科学基金-面上项目2024.01-2027.12100万3U23A20269基于时空多组学技术研究寒冷气候下病原感染导致免疫细胞稳态失衡的机制及干预策略刘迪国家自然科学基金重点项目(合作单位）...
